Prototype device for endoventricular beta-emitting radiotracer detection and molecularly-guided intervention.

ABSTRACT:

Background

We have set out to develop a catheter-based theranostic system that: (a) identifies diseased and at-risk myocardium via endocardial detection of systemically delivered β-emitting radiotracers and (b) utilizes molecular signals to guide delivery of therapeutics to appropriate tissue via direct intramyocardial injection.

Methods

Our prototype device consists of a miniature β-radiation detector contained within the tip of a flexible intravascular catheter. The catheter can be adapted to incorporate an injection port and retractable needle for therapeutic delivery. The performance of the β-detection catheter was assessed in vitro with various β-emitting radionuclides and ex vivo in hearts of pigs following systemic injection of ¹⁸F-fluorodeoxyglucose (

SUBMITTER: Stendahl JC 

PROVIDER: S-EPMC7895860 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature