Imaging atelectrauma in Ventilator-Induced Lung Injury using 4D X-ray microscopy.

ABSTRACT: Mechanical ventilation can damage the lungs, a condition called Ventilator-Induced Lung Injury (VILI). However, the mechanisms leading to VILI at the microscopic scale remain poorly understood. Here we investigated the within-tidal dynamics of cyclic recruitment/derecruitment (R/D) using synchrotron radiation phase-contrast imaging (PCI), and the relation between R/D and cell infiltration, in a model of Acute Respiratory Distress Syndrome in 6 anaesthetized and mechanically ventilated New-Zealand White rabbits. Dynamic PCI was performed at 22.6 µm voxel size, under protective mechanical ventilation [tidal volume: 6 ml/kg; positive end-expiratory pressure (PEEP): 5 cmH₂O]. Videos and quantitative maps of within-tidal R/D showed that injury propagated outwards from non-aerated reg

SUBMITTER: Fardin L 

PROVIDER: S-EPMC7895928 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature