Tolerance engineering in Deinococcus geothermalis by heterologous efflux pumps.

ABSTRACT: Producing industrially significant compounds with more environmentally friendly represents a challenging task. The large-scale production of an exogenous molecule in a host microfactory can quickly cause toxic effects, forcing the cell to inhibit production to survive. The key point to counter these toxic effects is to promote a gain of tolerance in the host, for instance, by inducing a constant flux of the neo-synthetized compound out of the producing cells. Efflux pumps are membrane proteins that constitute the most powerful mechanism to release molecules out of cells. We propose here a new biological model, Deinococcus geothermalis, organism known for its ability to survive hostile environment; with the aim of coupling the promising industrial potential of this species with that of hete

SUBMITTER: Boulant E 

PROVIDER: S-EPMC7896070 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature