Ontology highlight
ABSTRACT:
SUBMITTER: Greber BJ
PROVIDER: S-EPMC7896097 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Biophysical journal 20210119 4
The human CDK-activating kinase (CAK), composed of CDK7, cyclin H, and MAT1, is involved in the control of transcription initiation and the cell cycle. Because of these activities, it has been identified as a promising target for cancer chemotherapy. A number of CDK7 inhibitors have entered clinical trials, among them ICEC0942 (also known as CT7001). Structural information can aid in improving the affinity and specificity of such drugs or drug candidates, reducing side effects in patients. Here, ...[more]