Clinical, virologic and immunologic features of a mild case of SARS-CoV-2 reinfection.

ABSTRACT:

Objectives

To report a case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection 6 months after the first infection in a young healthy female physician. Both episodes led to mild coronavirus disease 2019 (COVID-19).

Methods

SARS-CoV-2 infections were detected by real-time reverse transcriptase PCR (RT-PCR) on nasopharyngeal specimens. Reinfection was confirmed by whole-genome sequencing. Kinetics of total anti-S receptor binding domain immunoglobulins (Ig anti-S RBD), anti-nucleoprotein (anti-N) and neutralizing antibodies were determined in serial serum samples retrieved during both infection episodes. Memory B-cell responses were assessed at day 12 after reinfection.

Results

Whole-genome sequencing identified two different SARS-CoV-2 genomes b

SUBMITTER: Vetter P 

PROVIDER: S-EPMC7896115 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature