Dynamic changes in the systemic immune responses of spinal cord injury model mice.

ABSTRACT: Intraspinal inflammatory and immune responses are considered to play central roles in the pathological development of spinal cord injury. This study aimed to decipher the dynamics of systemic immune responses, initiated by spinal cord injury. The spinal cord in mice was completely transected at T8. Changes in the in vivo inflammatory response, between the acute and subacute stages, were observed. A rapid decrease in C-reactive protein levels, circulating leukocytes and lymphocytes, spleen-derived CD4⁺ interferon-γ⁺ T-helper cells, and inflammatory cytokines, and a marked increase in neutrophils, monocytes, and CD4⁺CD25⁺FOXP3⁺ regulatory T-cells were observed during the acute phase. These systemic immune alterations were gradually resto

SUBMITTER: Gao TY 

PROVIDER: S-EPMC7896203 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature