Secretagogin marks amygdaloid PKCδ interneurons and modulates NMDA receptor availability.

ABSTRACT: The perception of and response to danger is critical for an individual's survival and is encoded by subcortical neurocircuits. The amygdaloid complex is the primary neuronal site that initiates bodily reactions upon external threat with local-circuit interneurons scaling output to effector pathways. Here, we categorize central amygdala neurons that express secretagogin (Scgn), a Ca²⁺-sensor protein, as a subset of protein kinase Cδ (PKCδ)⁺ interneurons, likely "off cells." Chemogenetic inactivation of Scgn⁺/PKCδ⁺ cells augmented conditioned response to perceived danger in vivo. While Ca²⁺-sensor proteins are typically implicated in shaping neurotransmitter release presynaptically, Scgn instead localized to postsynaptic compartments. Ch

SUBMITTER: Hevesi Z 

PROVIDER: S-EPMC7896286 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature