Cognitive trajectories of patients with focal ß-amyloid deposition.

ABSTRACT:

Background

The presence of ß-amyloid (Aß) in the brain can be identified using amyloid PET. In clinical practice, the amyloid PET is interpreted based on dichotomous visual rating, which renders focal Aß accumulation be read as positive for Aß. However, the prognosis of patients with focal Aß deposition is not well established. Thus, we investigated cognitive trajectories of patients with focal Aß deposition.

Methods

We followed up 240 participants (112 cognitively unimpaired [CU], 78 amnestic mild cognitive impairment [aMCI], and 50 Alzheimer's disease (AD) dementia [ADD]) for 2 years from 9 referral centers in South Korea. Participants were assessed with neuropsychological tests and ¹⁸F-flutemetamol (FMM) positron emission tomography (PET). Ten regions (frontal,

SUBMITTER: Kim SE 

PROVIDER: S-EPMC7896397 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature