Macrophage migration inhibitory factor may play a protective role in osteoarthritis.

ABSTRACT:

Background

Osteoarthritis (OA) is the most prevalent form of arthritis and the major cause of disability and overall diminution of quality of life in the elderly population. Currently there is no cure for OA, partly due to the large gaps in our understanding of its underlying molecular and cellular mechanisms. Macrophage migration inhibitory factor (MIF) is a procytokine that mediates pleiotropic inflammatory effects in inflammatory diseases such as rheumatoid arthritis (RA) and ankylosing spondylitis (AS). However, data on the role of MIF in OA is limited with conflicting results. We undertook this study to investigate the role of MIF in OA by examining MIF genotype, mRNA expression, and protein levels in the Newfoundland Osteoarthritis Study.

Methods

One hundred nineteen e

SUBMITTER: Liu M 

PROVIDER: S-EPMC7896408 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature