Telomere length dynamics over 10-years and related outcomes in patients with COPD.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) has been proposed as a disease of accelerated aging. Several cross-sectional studies have related a shorter telomere length (TL), a marker of biological aging, with COPD outcomes. Whether accelerated telomere shortening over time relates to worse outcomes in COPD patients, is not known.

Methods

Relative telomere length (T/S) was determined by qPCR in DNA samples from peripheral blood in 263 patients at baseline and up to 10 years post enrolment. Yearly clinical and lung function data of 134 patients with at least two-time measures of T/S over this time were included in the analysis.

Results

At baseline, T/S inversely correlated with age (r = - 0.236; p < 0.001), but there was no relationship between T/S and clini

SUBMITTER: Cordoba-Lanus E 

PROVIDER: S-EPMC7896411 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature