Landscape of phase 1 clinical trials for minors with cancer in the United States.

ABSTRACT:

Objectives

Understanding trends in characteristics of early phase trials that allow minors with cancer to participate may inform additional efforts to improve cancer drug development for young people.

Methods

We accessed data for oncology phase 1 or phase 1/2 trials in the United States from ClinicalTrials.gov with lower age bound for eligibility <18 years. Descriptive statistics were calculated and trends over time evaluated using logistic and multinomial logistic regression.

Results

Six hundred twelve trials met inclusion criteria. Sixty-five percent of trials were for older adults that also allowed minors, while 9% were exclusively for patients ≤18 years of age. Eighty-three percent of trials included at least one novel agent, while 17% studied only conventional th

SUBMITTER: Nader JH 

PROVIDER: S-EPMC7896417 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature