Regulation of chemoconvulsant-induced seizures by store-operated Orai1 channels.

ABSTRACT:

Key points

Temporal lobe epilepsy is a complex neurological disease caused by imbalance of excitation and inhibition in the brain. Growing literature implicates altered Ca²⁺ signalling in many aspects of epilepsy but the diversity of Ca²⁺ channels that regulate this syndrome are not well-understood. Here, we report that mice lacking the store-operated Ca²⁺ channel, Orai1, in the brain show markedly stronger seizures in response to the chemoconvulsants, kainic acid and pilocarpine. Electrophysiological analysis reveals that selective deletion of Orai1 channels in inhibitory neurons disables chemoconvulsant-induced excitation of GABAergic neurons in the CA1 hippocampus. Likewise, deletion of Orai1 in GABAergic neurons abrogates the chemoconvulsant-ind

SUBMITTER: Hori K 

PROVIDER: S-EPMC7896430 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature