Stroke increases the expression of ACE2, the SARS-CoV-2 binding receptor, in murine lungs.

ABSTRACT:

Background

The newly emerged severe acute respiratory syndrome coronavirus (SARS-CoV-2) has caused a worldwide pandemic of human respiratory disease. Angiotensin-converting enzyme (ACE) 2 is the key receptor on lung epithelial cells to facilitate initial binding and infection of SARS-CoV-2. The binding to ACE2 is mediated via the spike glycoprotein present on the viral surface. Recent clinical data have demonstrated that patients with previous episodes of brain injuries are a high-risk group for SARS-CoV-2 infection. An explanation for this finding is currently lacking. Sterile tissue injuries including stroke induce the release of several inflammatory mediators that might modulate the expression levels of signaling proteins in distant organs. Whether systemic inflammation followin

SUBMITTER: Singh V 

PROVIDER: S-EPMC7896496 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature