Inased (inhaled sedation in ICU) trial protocol: a multicentre randomised open-label trial.

ABSTRACT:

Introduction

The use of sedation in intensive care units (ICUs) is necessary and ubiquitous. The impact of sedation strategy on outcome, particularly when delivered early after initiation of mechanical ventilation, is unknown. Evidence is increasing that volatile anaesthetic agents could be associated with better outcome. Their use in delirium prevention is unknown.

Methods and analysis

This study is an investigator-initiated, prospective, multicentre, two-arm, randomised, control, open-trial comparing inhaled sedation strategy versus intravenous sedation strategy in mechanically ventilated patients in ICU. Two hundred and fifty patients will be randomly assigned to the intravenous sedation group or inhaled sedation group, with a 1:1 ratio in two groups according to the seda

SUBMITTER: Bailly P 

PROVIDER: S-EPMC7896597 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature