Single-cell transcriptomics analysis of mild cognitive impairment in World Trade Center disaster responders.

ABSTRACT:

Introduction

Recent research has found that World Trade Center (WTC) responders in their mid-50s have an elevated prevalence of mild cognitive impairment (MCI) that is associated with neural degeneration and subcortical thinning. This article extends our understanding of the molecular complexity of MCI through gene expression profiling of blood.

Methods

The transcriptomics of 40 male WTC responders were profiled across two cohorts (discovery: nine MCI and nine controls; replication: 11 MCI and 11 controls) using CITE-Seq at single-cell resolution in blood.

Results

Comparing the transcriptomic signatures across seven major cell subpopulations, the largest differences were observed in monocytes in which 226 genes were differentially expressed. Pathway analysis on the ge

SUBMITTER: Kuan PF 

PROVIDER: S-EPMC7896635 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature