On the estimation of inbreeding depression using different measures of inbreeding from molecular markers.

ABSTRACT: The inbreeding coefficient (F) of individuals can be estimated from molecular marker data, such as SNPs, using measures of homozygosity of individual markers or runs of homozygosity (ROH) across the genome. These different measures of F can then be used to estimate the rate of inbreeding depression (ID) for quantitative traits. Some recent simulation studies have investigated the accuracy of this estimation with contradictory results. Whereas some studies suggest that estimates of inbreeding from ROH account more accurately for ID, others suggest that inbreeding measures from SNP-by-SNP homozygosity giving a large weight to rare alleles are more accurate. Here, we try to give more light on this issue by carrying out a set of computer simulations considering a range of populat

SUBMITTER: Caballero A 

PROVIDER: S-EPMC7896712 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature