Quantitative T1 mapping of the normal brain from early infancy to adulthood.

ABSTRACT:

Background

Quantitative mapping of MRI relaxation times is expected to uncover pathological processes in the brain more subtly than standard MRI techniques with weighted contrasts. So far, however, most mapping techniques suffer from a long measuring time, low spatial resolution or even sensitivity to magnetic field inhomogeneity.

Objective

To obtain T1 relaxation times of the normal brain from early infancy to adulthood using a novel technique for fast and accurate T1 mapping at high spatial resolution.

Materials and methods

We performed whole-brain T1 mapping within less than 3 min in 100 patients between 2 months and 18 years of age with normal brain at a field strength of 3 T. We analyzed T1 relaxation times in several gray-matter nuclei and white matter. Subseque

SUBMITTER: Grafe D 

PROVIDER: S-EPMC7897197 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature