Chronic opioid use is associated with early biologic discontinuation in inflammatory bowel disease.

ABSTRACT:

Background

Chronic opioid use is associated with poorer clinical outcomes in inflammatory bowel disease.

Aims

To investigate an association between chronic opioid use and persistence with biologic agents in management of inflammatory bowel disease.

Methods

A total of 16 624 patients diagnosed with inflammatory bowel disease and receiving a first-time biologic prescription from 2011 to 2016 were identified retrospectively from the Truven MarketScan Database. A cohort of 1768 patients were identified as chronic opioid users utilising outpatient prescription claims. Utilisation patterns of biologic therapies were assessed from inpatient administration and outpatient claims data, including persistence calculations. Information on healthcare utilisation and common comorbid

SUBMITTER: Rhudy C 

PROVIDER: S-EPMC7897267 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature