Childhood Neurotoxicity and Brain Resilience to Adverse Events during Adulthood.

ABSTRACT:

Objective

This study used childhood cancer survivors as a novel model to study whether children who experience central nervous system (CNS) injury are at higher risk for neurocognitive impairment associated with subsequent late onset chronic health conditions (CHCs).

Methods

Adult survivors of childhood cancer (n = 2,859, ≥10 years from diagnosis, ≥18 years old) completed a comprehensive neurocognitive battery and clinical examination. Neurocognitive impairment was defined as age-adjusted z score < 10th percentile. Participants impaired on ≥3 tests had global impairment. CHCs were graded using the Common Terminology Criteria for Adverse Events v4.3 (grade 1, mild; 2, moderate; 3, severe/disabling; 4, life-threatening) and were combined into a severity/burden score by frequen

SUBMITTER: Williams AM 

PROVIDER: S-EPMC7897299 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature