Endometrial biomarkers in premenopausal women with obesity: an at-risk cohort.

ABSTRACT:

Background

Obesity is a well-known risk factor for endometrial cancer, but the mechanisms of obesity-related carcinogenesis are not well defined, particularly for premenopausal women. With the continuing obesity epidemic, increases in the incidence of endometrial cancer and a younger age of diagnosis are often attributed to a hyperestrogenic state created by hormone production in adipose tissue, but significant knowledge gaps remain. The balance of estrogen-responsive signals has not been defined in the endometrium of premenopausal women with obesity, where obesity may not create hyperestrogenism in the context of ovaries being the primary source of estrogen production. Obesity is associated with a state of low-grade, chronic inflammation that can promote tumorigenesis, and it is a

SUBMITTER: Dottino JA 

PROVIDER: S-EPMC7897335 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature