A meta-analysis of HDL cholesterol efflux capacity and concentration in patients with rheumatoid arthritis.

ABSTRACT:

Background

Poor cholesterol efflux capacity (CEC) has been proposed to be an independent risk factor for cardiovascular diseases. However, current evidence is inconsistent, especially in rheumatoid arthritis (RA) patients. This meta-analysis aims to identify whether CEC is impaired or altered by drug therapy in RA.

Methods

The PubMed/MEDLINE, Embase, Cochrane Library and ClinicalTrials.gov databases were browsed to identify studies on CEC in RA patients. The searches mainly focused on studies in human subjects that were published before November 14, 2020, without any language restrictions. The effect size was pooled by the standardized mean differences and mean differences (SMD & MD) as well as the corresponding 95% confidence intervals (CIs) in a random or fixed effect mode

SUBMITTER: Xie B 

PROVIDER: S-EPMC7897392 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature