Ontology highlight
ABSTRACT:
SUBMITTER: Gu VW
PROVIDER: S-EPMC7897584 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Gu Vivian W VW Cho Edward E Thompson Dakota T DT Cassady Victoria C VC Borcherding Nicholas N Koch Kelsey E KE Wu Vincent T VT Lorenzen Allison W AW van der Heide Dana M DM White Jeffrey R JR Kulak Mikhail V MV Williams Trevor T Zhang Weizhou W Weigel Ronald J RJ
Stem cell reports 20201230 1
Mammary gland ductal morphogenesis depends on the differentiation of mammary stem cells (MaSCs) into basal and luminal lineages. The AP-2γ transcription factor, encoded by Tfap2c, has a central role in mammary gland development but its effect in mammary lineages and specifically MaSCs is largely unknown. Here, we utilized an inducible, conditional knockout of Tfap2c to elucidate the role of AP-2γ in maintenance and differentiation of MaSCs. Loss of AP-2γ in the basal epithelium profoundly altere ...[more]