Clinical significance of checkpoint regulator "Programmed death ligand-1 (PD-L1)" expression in meningioma: review of the current status.

ABSTRACT:

Introduction

Meningioma is the most common primary brain tumor. Most meningiomas are benign; however, a subset of these tumors can be aggressive, presenting with early or multiple tumor recurrences that are refractory to neurosurgical resection and radiotherapy. There is no standard systemic therapy for these patients, and post-surgical management of these patients is usually complicated due to lack of accurate prediction for tumor progression.

Methods

In this review, we summarise the crucial immunosuppressive role of checkpoint regulators, including PD-1 and PD-L1 interacting in the tumor microenvironment, which has led to efforts aimed at targeting this axis.

Results

Since their discovery, checkpoint inhibitors have significantly improved the outcome in many types o

SUBMITTER: Karimi S 

PROVIDER: S-EPMC7897616 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature