Long Non-Coding RNAs as Key Modulators of Pancreatic β-Cell Mass and Function.

ABSTRACT: Numerous studies have sought to decipher the genetic and other mechanisms contributing to β-cell loss and dysfunction in diabetes mellitus. However, we have yet to fully understand the etiology of the disease or to develop satisfactory treatments. Since the majority of diabetes susceptibility loci are mapped to non-coding regions within the genome, understanding the functions of non-coding RNAs in β-cell biology might provide crucial insights into the pathogenesis of type 1 (T1D) and type 2 (T2D) diabetes. During the past decade, numerous studies have indicated that long non-coding RNAs play important roles in the maintenance of β-cell mass and function. Indeed, lncRNAs have been shown to be involved in controlling β-cell proliferation during development and/or β-cell compensation i

SUBMITTER: Lopez-Noriega L 

PROVIDER: S-EPMC7897662 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature