The Systemic and Cellular Metabolic Phenotype of Infection and Immune Response to Listeria monocytogenes.

ABSTRACT: It is widely accepted that infection and immune response incur significant metabolic demands, yet the respective demands of specific immune responses to live pathogens have not been well delineated. It is also established that upon activation, metabolic pathways undergo shifts at the cellular level. However, most studies exploring these issues at the systemic or cellular level have utilized pathogen associated molecular patterns (PAMPs) that model sepsis, or model antigens at isolated time points. Thus, the dynamics of pathogenesis and immune response to a live infection remain largely undocumented. To better quantitate the metabolic demands induced by infection, we utilized a live pathogenic infection model. Mice infected with Listeria monocytogenes were monitored longitudinally ov

SUBMITTER: Johnson RM 

PROVIDER: S-EPMC7897666 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature