Innate Immunity Mediated Inflammation and Beta Cell Function: Neighbors or Enemies?

ABSTRACT: Type 1 diabetes (T1D) is still considered a huge burden because the available treatments are not effective in preventing the onset or progression of the disease. Recently, the idea that diabetes is an autoimmune disease mediated exclusively by T cells has been reshaped. In fact, T cells are not the only players with an active role in beta cell destruction. Macrophages and neutrophils, which physiologically reside in pancreatic tissue, can also participate in tissue homeostasis and damage by promoting innate immune responses and modulating inflammation. During the development of the pancreatic islet inflammation there is a strong interplay of both adaptive and innate immune cells, and the presence of innate immune cells has been demonstrated both in exocrine and endocrine pancreatic compart

SUBMITTER: Citro A 

PROVIDER: S-EPMC7897669 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature