Routine use of immunosuppressants is associated with mortality in hospitalised patients with COVID-19.

ABSTRACT:

Background

Whilst there is literature on the impact of SARS viruses in the severely immunosuppressed, less is known about the link between routine immunosuppressant use and outcome in COVID-19. Consequently, guidelines on their use vary depending on specific patient populations.

Methods

The study population was drawn from the COPE Study (COVID-19 in Older People), a multicentre observational cohort study, across the UK and Italy. Data were collected between 27 February and 28 April 2020 by trained data-collectors and included all unselected consecutive admissions with COVID-19. Load (name/number of medications) and dosage of immunosuppressant were collected along with other covariate data. Primary outcome was time-to-mortality from the date of admission (or) date of diagnosi

SUBMITTER: Myint PK 

PROVIDER: S-EPMC7897811 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature