Genetic aberrations in Chinese pancreatic cancer patients and their association with anatomic location and disease outcomes.

ABSTRACT:

Objectives

Pancreatic cancer (PC) is one of the most lethal malignancies with an increasing death rate over the years. We performed targeted sequencing and survival analyses on 90 Chinese pancreatic cancer patients, hoping to identify genomic biomarkers associated with clinical outcomes and therapeutic options.

Method

Genomic DNA was extracted from formalin-fixed paraffin-embedded (FFPE) tissue specimens of 90 pancreatic cancer patients and sequenced. The associations with clinicopathological factors were analyzed.

Result

High prevalence of driver mutations in KRAS, TP53, CDKN2A, SMAD4, and ARID1A genes were found. Most mutated genes in PC belonged to cell cycle and DNA damage repair pathways. Tumors that arise from the pancreas' body and tail (BT tumors) displayed a

SUBMITTER: Lu J 

PROVIDER: S-EPMC7897942 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature