Risk factors and predictors for tumor site origin in metastatic adenocarcinoma of unknown primary site.

ABSTRACT:

Background

Metastatic adenocarcinoma of unknown primary site (MACUP) is the most common cancer of unknown primary site, and shows worse prognosis. Prediction of its tumor site origin attracts a growing attention. However, the site determined by gene expression profiling does not have a significant impact on the survival. Some other special method might need to be found out.

Methods

We reviewed 1011 MACUP patients diagnosed by pathological examination and immunohistochemistry based on the Surveillance, Epidemiology, and End Results (SEER) database during 2010-2016. Kaplan-Meier curves and Cox proportional hazard model were analyzed to compare the survival. Logistic regression models and relevant nomograms were performed to predicting the probability of the primary site which

SUBMITTER: Li X 

PROVIDER: S-EPMC7897950 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature