AL amyloidosis: The effect of fluorescent in situ hybridization abnormalities on organ involvement and survival.

ABSTRACT:

Background

Systemic light chain (AL) amyloidosis is a clonal plasma-cell neoplasm that carries a poor prognosis. Although AL amyloidosis and Multiple Myeloma (MM) can co-exist and share various cytogenetic chromosomal abnormalities, little is known about Fluorescent in situ hybridization (FISH) and its prognostic relevance in AL amyloidosis.

Aim

The study aims to evaluate the most prevalent FISH cytogenetic abnormalities in AL patients as independent prognostic factors, and assess the impact of cytogenetics on the survival of high-risk cardiac AL patients.

Materials & methods

This retrospective study reviewed 113 consecutive AL patients treated at The Ohio State University (OSU). Patients were divided into subgroups based on FISH data obtained within 90 days of diagno

SUBMITTER: Ozga M 

PROVIDER: S-EPMC7897960 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature