Surveillance for radiation-related late effects in childhood cancer survivors: The impact of using volumetric dosimetry.

ABSTRACT:

Background

Radiation-related screening guidelines for survivors of childhood cancer currently use irradiated regions (IR) to determine risk for late effects. However, contemporary radiotherapy techniques utilize volumetric dosimetry (VD) to determine organ-specific exposures, which could inform need for late effect surveillance.

Methods

This cross-sectional cohort study involved patients treated for cancer using computerized tomography-planned irradiation at Children's Hospital Los Angeles from 2000-2016. Organs at risk were identified using both VD and IR. Under each method, Children's Oncology Group Long-Term Follow-Up Guidelines were applied to determine radiation-related potential late effects and their correlative recommended screening practices. Patients served as thei

SUBMITTER: Cohen-Cutler S 

PROVIDER: S-EPMC7897961 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature