Immune landscape and a promising immune prognostic model associated with TP53 in early-stage lung adenocarcinoma.

ABSTRACT:

Purpose

TP53 mutation, one of the most frequent mutations in early-stage lung adenocarcinoma (LUAD), triggers a series of alterations in the immune landscape, progression, and clinical outcome of early-stage LUAD. Our study was designed to unravel the effects of TP53 mutation on the immunophenotype of early-stage LUAD and formulate a TP53-associated immune prognostic model (IPM) that can estimate prognosis in early-stage LUAD patients.

Materials and methods

Immune-associated differentially expressed genes (DEGs) between TP53 mutated (TP53^MUT ) and TP53 wild-type (TP53^WT ) early-stage LUAD were comprehensively analyzed. Univariate Cox analysis and least absolute shrinkage and selection operator (LASSO) analysis identified the prognostic immune-associated

SUBMITTER: Wu C 

PROVIDER: S-EPMC7897963 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature