Cordifolioside: potent inhibitor against M^pro of SARS-CoV-2 and immunomodulatory through human TGF-β and TNF-α.

ABSTRACT: Therapeutic options for SARS-CoV-2 are limited merely to the symptoms or repurposed drugs and non-specific interventions to promote the human immune system. In the present study, chromatographic and in silico approaches were implemented to identify bioactive compounds which might play pivotal role as inhibitor for SARS-CoV-2 and human immunomodulator (TGF-β and TNF-α). Tinospora cordifolia (Willd.) Miers was evaluated for phenolic composition and explored for bioactive compounds by high-performance thin layer chromatography (HPTLC). Furthermore, the bioactive compounds such as cordifolioside, berberine, and magnoflorine were appraised as human immunomodulatory and potent inhibitor against Main Protease (M^pro) of SARS-CoV-2 through multiple docking strategies. Cordifoliosi

SUBMITTER: Manne M 

PROVIDER: S-EPMC7898013 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature