Pleiotropy and Cross-Disorder Genetics Among Psychiatric Disorders.

ABSTRACT: Genome-wide analyses of common and rare genetic variations have documented the heritability of major psychiatric disorders, established their highly polygenic genetic architecture, and identified hundreds of contributing variants. In recent years, these studies have illuminated another key feature of the genetic basis of psychiatric disorders: the important role and pervasive nature of pleiotropy. It is now clear that a substantial fraction of genetic influences on psychopathology transcend clinical diagnostic boundaries. In this review, we summarize evidence in psychiatry for pleiotropy at multiple levels of analysis: from overall genome-wide correlation to biological pathways and down to the level of individual loci. We examine underlying mechanisms of observed pleiotropy, including gene

SUBMITTER: Lee PH 

PROVIDER: S-EPMC7898275 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature