A systematic review and participant-level meta-analysis found little association of retinal microvascular caliber with reduced kidney function.

ABSTRACT: Previously, variation in retinal vascular caliber has been reported in association with chronic kidney disease (CKD) but findings remain inconsistent. To help clarify this we conducted individual participant data meta-analysis and aggregate data meta-analysis on summary estimates to evaluate cross-sectional associations between retinal vascular caliber and CKD. A systematic review was performed using Medline and EMBASE for articles published until October 2018. The aggregate analysis used a two-stage approach combining summary estimates from eleven studies (44,803 patients) while the individual participant analysis used a one-stage approach combining raw data from nine studies (33,222 patients). CKD stages 3-5 was defined as an estimated glomerular filtration rate under 60 mL/min/1.73m

SUBMITTER: Lye WK 

PROVIDER: S-EPMC7898278 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature