Comparison of preconcentration methods for nontargeted analysis of natural waters using HPLC-HRMS: Large volume injection versus solid-phase extraction.

ABSTRACT: Nontargeted analysis of water samples using liquid chromatography combined with high-resolution mass spectrometers is an emerging approach for surface water monitoring and evaluation of water treatment processes. In this study, sample preconcentration via direct, large volume injection with 500 μL and 1000 μL injection volumes was compared to SPE regarding analytical performance parameters in targeted and nontargeted workflows. In targeted analysis, the methods were evaluated in terms of LOD and intrabatch precision of the selected compounds, whereas in nontargeted analysis, the number of detected unknown compounds, the method's intra-batch precision, and the retention time versus molecular mass pattern of the detected unknowns were evaluated. In addition, a novel intensity drift correctio

SUBMITTER: Kutlucinar KG 

PROVIDER: S-EPMC7898308 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature