Energy-dependent protein folding: modeling how a protein folding machine may work.

ABSTRACT: Background: Proteins fold robustly and reproducibly in vivo, but many cannot fold in vitro in isolation from cellular components. Despite the remarkable progress that has been achieved by the artificial intelligence approaches in predicting the protein native conformations, the pathways that lead to such conformations, either in vitro or in vivo, remain largely unknown. The slow progress in recapitulating protein folding pathways in silico may be an indication of the fundamental deficiencies in our understanding of folding as it occurs in nature. Here we consider the possibility that protein folding in living cells may not be driven solely by the decrease in Gibbs free energy and propose that protein folding in vivo should be modeled as an a

SUBMITTER: Sahakyan H 

PROVIDER: S-EPMC7898354 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature