YAP and TAZ regulate Schwann cell proliferation and differentiation during peripheral nerve regeneration.

ABSTRACT: YAP and TAZ are effectors of the Hippo pathway that controls multicellular development by integrating chemical and mechanical signals. Peripheral nervous system development depends on the Hippo pathway. We previously showed that loss of YAP and TAZ impairs the development of peripheral nerve as well as Schwann cell myelination. The role of the Hippo pathway in peripheral nerve regeneration has just started to be explored. After injury, Schwann cells adopt new identities to promote regeneration by converting to a repair-promoting phenotype. While the reprogramming of Schwann cells to repair cells has been well characterized, the maintenance of such repair phenotype cannot be sustained for a very long period, which limits nerve repair in human. First, we show that short or long-term myelin m

SUBMITTER: Jeanette H 

PROVIDER: S-EPMC7898398 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature