IL-21 Promotes Intestinal Memory IgA Responses.

ABSTRACT: The role of IL-21, produced mainly by Th17 cells and T follicular helper cells, has been intensively investigated in B cell differentiation and Ab class switch. However, how IL-21 regulates memory IgA⁺ B cell development and memory IgA responses in the intestines is still not completely understood. In this study, we found the total IgA⁺ B cells as well as CD38⁺CD138^-IgA⁺ memory B cells were significantly increased in intestinal lamina propria (LP) of TCRβxδ^-/- mice after transfer of microbiota Ag-specific Th17 cells but not Th1 cells. Although IL-21R^-/- mice or IL-17R^-/- mice showed decreased Ag-specific memory IgA production in the intestines upon infection with Citrobacter rodentium, the percen

SUBMITTER: Huang X 

PROVIDER: S-EPMC7898419 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature