Tumor co-expression of progranulin and sortilin as a prognostic biomarker in breast cancer.

ABSTRACT:

Background

The growth factor progranulin has been implicated in numerous biological processes such as wound healing, inflammation and progressive tumorigenesis. Both progranulin and its receptor sortilin are known to be highly expressed in subgroups of breast cancer and have been associated with various clinical properties including tamoxifen resistance. Recent data further suggest that progranulin, via its receptor sortilin, drives breast cancer stem cell propagation in vitro and increases metastasis formation in an in vivo breast cancer xenograft model. In this retrospective biomarker analysis, we aimed to determine whether tumor co-expression of progranulin and sortilin has prognostic and treatment predictive values for breast cancer patients.

Methods

We explored how co-e

SUBMITTER: Berger K 

PROVIDER: S-EPMC7898426 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature