Modeling the potential impact of administering vaccines against Clostridioides difficile infection to individuals in healthcare facilities.

ABSTRACT:

Background

A vaccine against Clostridioides difficile infection (CDI) is in development. While the vaccine has potential to both directly protect those vaccinated and mitigate transmission by reducing environmental contamination, the impact of the vaccine on C. difficile colonization remains unclear. Consequently, the transmission-reduction effect of the vaccine depends on the contribution of symptomatic CDI to overall transmission of C. difficile.

Methods

We designed a simulation model of CDI among patients in a network of 10 hospitals and nursing homes and calibrated the model using estimates of transmissibility from whole genome sequencing studies that estimated the fraction of CDI attributable to transmission from other CDI patients. We assumed the vaccine reduced the ra

SUBMITTER: Toth DJA 

PROVIDER: S-EPMC7898464 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature