Systematic review with meta-analysis: the effects of immunomodulator or biological withdrawal from mono- or combination therapy in inflammatory bowel disease.

ABSTRACT:

Background

Withdrawal of treatment is a common therapeutic problem in patients with long-standing remission of inflammatory bowel disease.

Aims

To evaluate the relapse rate in patients with quiescent inflammatory bowel disease after cessation of biologic or immunomodulator therapy.

Methods

We searched five databases for studies evaluating disease relapse after withdrawal of monotherapy or a drug from combination therapy in Crohn's disease or ulcerative colitis. In meta-analysis, risk ratios (RR) were calculated with 95% confidence intervals (CI).

Results

Ten randomised controlled trials (587 patients) were included in the meta-analysis, and another nine studies in systematic review. Withdrawal of immunomodulator monotherapy resulted in a significantly higher ri

SUBMITTER: Dohos D 

PROVIDER: S-EPMC7898479 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature