An Integrated Strategy for Effective-Component Discovery of Astragali Radix in the Treatment of Lung Cancer.

ABSTRACT: Lung cancer is one of the most devastating diseases worldwide, with high incidence and mortality worldwide, and the anticancer potential of traditional Chinese medicine (TCM) has been gradually recognized by the scientific community. Astragali Radix (AR) is commonly used in traditional Chinese medicine in the treatment of lung cancer and has a certain clinical effect, but effective components and targets are still unclear. In the study, we established an integrated strategy for effective-component discovery of AR in the treatment of lung cancer based on a variety of techniques. First, the effective components and potential targets of AR were deciphered by the "component-target-disease" network using network pharmacology, and potential signal pathways on lung cancer were predicted by Gene O

SUBMITTER: Yang B 

PROVIDER: S-EPMC7898675 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature