The Burden of the Serious and Difficult-to-Treat Infections and a New Antibiotic Available: Cefiderocol.

ABSTRACT: Background: Infection is a disease that can occur due to the entrance of a virus, bacteria, and other infectious agents. Cefiderocol is innovative cephalosporin drug that belongs to a special class of antibiotics, sideromycins, which are taken up by bacterial cells through active transport. The unique cell entry and stability to β-lactamases allow cefiderocol to overcome the most common resistance mechanisms in Gram-negative bacteria. Objective: This article aims to highlight the therapeutic efficacy, safety and tolerability of cefiderocol, with a focus on the FDA label. Methods: The pharmacological properties of cefiderocol are also summarized. In this review, we conducted literature research on the PubMed database using the following keywords: "antimicrobial treatmen

SUBMITTER: Taheri Y 

PROVIDER: S-EPMC7898678 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature