Toward nonparametric diffusion- T1 characterization of crossing fibers in the human brain.

ABSTRACT:

Purpose

To estimate T1 for each distinct fiber population within voxels containing multiple brain tissue types.

Methods

A diffusion- T1 correlation experiment was carried out in an in vivo human brain using tensor-valued diffusion encoding and multiple repetition times. The acquired data were inverted using a Monte Carlo algorithm that retrieves nonparametric distributions P(D,R1) of diffusion tensors and longitudinal relaxation rates R1=1/T1 . Orientation distribution functions (ODFs) of the highly anisotropic components of P(D,R1) were defined to visualize orientation-specific diffusion-relaxation properties. Finally, Monte Carlo density-peak clustering (MC-DPC) was performed to quantify fiber-specific features and investigate microstructural differences between white matt

SUBMITTER: Reymbaut A 

PROVIDER: S-EPMC7898694 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature