Comparison of single-channel EEG, actigraphy, and sleep diary in cognitively normal and mildly impaired older adults.

ABSTRACT:

Study objectives

Multiple methods for monitoring sleep-wake activity have identified sleep disturbances as risk factors for Alzheimer disease (AD). In order to identify the level of agreement between different methods, we compared sleep parameters derived from single-channel EEG (scEEG), actigraphy, and sleep diaries in cognitively normal and mildly impaired older adults.

Methods

Two hundred ninety-three participants were monitored at home for up to six nights with scEEG, actigraphy, and sleep diaries. Total sleep time (TST), sleep efficiency (SE), sleep onset latency (SOL), and wake after sleep onset (WASO) were calculated using each of these methods. In 109 of the 293 participants, the ratio of cerebrospinal fluid concentrations of phosphorylated tau (p-tau) and amyloid-β-

SUBMITTER: Chou CA 

PROVIDER: S-EPMC7898727 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature