A scoping review of studies using observational data to optimise dynamic treatment regimens.

ABSTRACT:

Background

Dynamic treatment regimens (DTRs) formalise the multi-stage and dynamic decision problems that clinicians often face when treating chronic or progressive medical conditions. Compared to randomised controlled trials, using observational data to optimise DTRs may allow a wider range of treatments to be evaluated at a lower cost. This review aimed to provide an overview of how DTRs are optimised with observational data in practice.

Methods

Using the PubMed database, a scoping review of studies in which DTRs were optimised using observational data was performed in October 2020. Data extracted from eligible articles included target medical condition, source and type of data, statistical methods, and translational relevance of the included studies.

Results

From 2

SUBMITTER: Mahar RK 

PROVIDER: S-EPMC7898728 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature