Diagnostic Accuracy of Biomarkers of Alcohol Use in Patients With Liver Disease: A Systematic Review.

ABSTRACT:

Background and aims

Alcohol-related liver disease is the most frequent cause of cirrhosis and a major indication for liver transplantation. Several alcohol use biomarkers have been developed in recent years and are already in use in several centers. However, in patients with liver disease their diagnostic performance might be influenced by altered biomarker formation by hepatic damage, altered excretion by kidney dysfunction and diuretics use, and altered deposition in hair and nails. We systematically reviewed studies on the diagnostic accuracy of biomarkers of alcohol use in patients with liver disease and performed a detailed study quality assessment.

Methods

A structured search in PubMed/Medline/Embase databases was performed for relevant studies, published until April 2

SUBMITTER: Arnts J 

PROVIDER: S-EPMC7898850 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature