The effect of semaglutide 2.4 mg once weekly on energy intake, appetite, control of eating, and gastric emptying in adults with obesity.

ABSTRACT:

Aim

To investigate the effects of once-weekly subcutaneous (s.c.) semaglutide 2.4 mg on gastric emptying, appetite, and energy intake in adults with obesity.

Materials and methods

A double-blind, parallel-group trial was conducted in 72 adults with obesity, randomized to once-weekly s.c. semaglutide (dose-escalated to 2.4 mg) or placebo for 20 weeks. Gastric emptying was assessed using paracetamol absorption following a standardized breakfast. Participant-reported appetite ratings and Control of Eating Questionnaire (CoEQ) responses were assessed, and energy intake was measured during ad libitum lunch.

Results

The area under the concentration-time curve (AUC) for paracetamol 0 to 5 hours after a standardized meal (AUC_0-5h,para ; primary endpoint) was increa

SUBMITTER: Friedrichsen M 

PROVIDER: S-EPMC7898914 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature