Follicular regulatory helper T cells control the response of regulatory B cells to a high-cholesterol diet.

ABSTRACT:

Aims

B cell functions in the process of atherogenesis have been investigated but several aspects remain to be clarified.

Methods and results

In this study, we show that follicular regulatory helper T cells (TFR) control regulatory B cell (BREG) populations in Apoe-/- mice models on a high-cholesterol diet (HCD). Feeding mice with HCD resulted in up-regulation of TFR and BREG cell populations, causing the suppression of proatherogenic follicular helper T cell (TFH) response. TFH cell modulation is correlated with the growth of atherosclerotic plaque size in thoracoabdominal aortas and aortic root plaques, suggesting that TFR cells are atheroprotective. During adoptive transfer experiments, TFR cells transferred into HCD mice decreased TFH cell populations, atherosclerotic pla

SUBMITTER: Burger F 

PROVIDER: S-EPMC7898950 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature